Pediatric corneal diseases encompass a diverse group of ocular disorders that, if not managed appropriately, can result in amblyopia and significant vision loss. These conditions also profoundly impact the quality of life for affected children. This chapter explores the clinical presentations and management approaches for five distinct pediatric corneal cases. Key topics include dupilumab-associated conjunctivitis, the ocular manifestations of Keratitis-Ichthyosis-Deafness (KID) syndrome, exposure keratopathy, Thygeson’s superficial punctate keratitis, and keratoconus.