Waste management challenges in the Global South are due to various reasons related to rapid urbanization, massive waste stream, improper waste collection and sorting, inadequate policies, and inappropriate treatment and recycling systems which contribute to environmental pollution, public health risks, and hindered sustainable development. Waste in the Global South is from plastics, electronics, organic, industries, clinics, construction, and demolition sites. The GS bioeconomy strategy for waste management continually involves an expansive and sustainable approach, incorporating various technologies to support biological resources efficiently. The strategies adopt biological treatments, bioenergy production, bioremediation, circular economy practices, sustainable agriculture, bioplastics, and biobased materials, with research and innovations. Noticeably, electronic waste is significant in the Global South. Improper disposal of electronic devices leads to environmental contamination and health hazards due to the presence of harmful components and heavy metals, making it a pressing concern for public health and the environment. Mechanical shredding and sorting, pyrometallurgical and hydrometallurgical processes, biotechnological methods, recycling, and refining technologies have been adopted to convert e-waste to valuable materials. Similarly, mechanical, pyrolysis, and chemical recycling, among others, have been adopted in converting plastic wastes. Autoclaving, microwave treatment, waste-to-energy, chemical disinfection, shredding, and compaction are adopted to ensure safe and responsible disposal of medical waste. Composting methods, anaerobic digestion, bioconversion, and gasification are adopted in converting organic waste to valuable products. Technologies convert various types of waste into valuable resources energy or recycled materials. Others contribute to value in terms of resource recovery and environmental impact reduction. Implementing such solutions can contribute to sustainable development, reduce pollution, and foster innovation in the regions facing waste management issues. A predicted future gap in the waste-to-value technology in the GS can simply be bridged with improved infrastructure and accessible technology. Other key elements to tackle are regulatory frameworks, awareness and education, financial barriers, and e-waste complexity. Collaborative efforts with governments, private sectors, and communities are mandatory to promote research, investment, and development of sustainable waste-to-value solutions in the Global South.