High efficiency, high output waveform quality and low stress switching are among the principal requirements for the power converter design. This paper investigates the design and control of a 3-level Active Neutral Point Clamped (ANPC) grid-tied inverters to meet these requirements. A new PWM switching strategy is designed for power loss reduction in the control of ANPCs that use hybrid Si and WBG switching devices. The locations of switching devices made of different materials in the circuit are investigated, and the power losses and switching stresses under different PWM control strategies are compared. The power losses due to both conduction and switching for each switching device and the whole circuit are evaluated. Simulation results confirm that both the converter design and the PWM control strategy need to be optimized together for the best trade-off among different objectives, such as the power losses and the cost.