Seed germination and seedling development are critical processes in the growth and establishment of vegetable crops. Germination is initiated by water absorption, which triggers biochemical changes and the activation of enzymes in the seed. This chapter explores the intricate process of seed germination and seedling development in vegetable crops, with a primary focus on the role of growth regulation and quality enhancement. The germination phase is a critical period that lays the foundation for a plant’s growth trajectory and final yield. Temperature, light, moisture, and hormonal balance significantly influence germination success. Growth regulators, including phytohormones, are instrumental in orchestrating key developmental events during seedling establishment. High-quality seeds are essential for successful crop production, with germination potential, seed health, and genetic and physical purity being critical components of seed quality. The quality of vegetables encompasses attributes such as nutritional content, appearance, taste, and resistance to stressors. Various growth regulators and innovative cultivation techniques are being employed to manipulate these traits positively. This chapter highlights the importance of quality seeds, mechanisms of seed germination, molecular aspects and approaches to speed up seed germination and seedling development in vegetable crops.