According to the majority of the studies, adding nano-particles to lubricating oils and refrigerants enhances a fluid's performance coefficient by improving the thermal mechanics of the pure substance, which reduces energy consumption. According to previous research, the coefficient of performance of refrigeration systems utilizing nanomaterial based refrigerant is always better than that of a traditional refrigeration system. In the present experimental study, refrigerants pure R134a, pure R290, blends of R134a + R290, and mixtures of pure refrigerants with CuO nanaparticles, also known as nano refrigerants, are all used to analyse the performance of the refrigeration system. In comparison to the traditional refrigerant, the coefficient of performance of the nano-refrigerant combination is enhanced. Additionally, it has been shown that when the nanoparticle concentration is increased above a specific limit, undesirable consequences also seen, such as temperature decreases at a rapid rate in the condenser and evaporator. The system's coefficient of performance was found to rise as compared to traditional refrigerant, while power consumption was found to reduce by (10.4%).