The growing global demand for sustainable energy and efficient waste management necessitates innovative conversion pathways for municipal and sanitary waste. Sanitary diaper waste, owing to its non-biodegradable composition and high disposal volume, poses a persistent environmental challenge. This study evaluates the techno-economic feasibility of producing syngas from sanitary diaper waste through CO2-assisted co-gasification, integrating both environmental and economic perspectives. The analysis considers plant-scale parameters such as fixed and operational costs, manufacturing expenses, and payback period to assess overall project viability. The techno-economic evaluation for an industrial-scale plant processing 1000 kg/day of feedstock revealed a fixed cost of INR2.7 million, an annual operating cost of INR5.33 million, and a manufacturing cost of INR32.27 per kg of syngas, with a payback period of 10.32 years. These findings demonstrate that CO2-assisted co-gasification of sanitary diaper waste is a technically feasible and economically sustainable approach for renewable syngas production, contributing to circular-economy objectives and reduced carbon emissions through decentralized waste-to-energy systems.