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Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition with limited treatment options. Terahertz (THz) waves have shown neuromodulatory and behavioral benefits in preclinical models. The hippocampus—a key substrate for cognitive processing—is critically implicated in PTSD pathogenesis, yet how terahertz waves modulate hippocampal gene expression to exert long-term biological effects is unknown. Utilizing a PTSD mouse model, we delivered in vivo 34.5 THz irradiation via a quantum cascade laser coupled to an AgCl:AgBr optical fiber. RNA sequencing of the hippocampus revealed 335 differentially expressed genes (DEGs) (107 up-regulated, 218 down-regulated) post-irradiation. Gene Ontology enrichment analysis implicated these DEGs in critical biological processes, including neurodevelopment, apoptosis regulation, and immune response. Kyoto Encyclopedia of Genes and Genomes pathway analysis further identified significant enrichment in MAPK, TGF-β, GnRH, and ErbB signaling pathways. These findings suggest that THz irradiation may alleviate cognitive deficits in PTSD by modulating neurodevelopmental and immunoregulatory processes through the regulation of key signaling pathways such as MAPK and TGF-β. This study provides initial mechanistic insights into the potential therapeutic application of THz waves for PTSD-related cognitive dysfunction.

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Terahertz Wave Modulation of Hippocampal Gene Expression in a Mouse Model of Post-traumatic Stress Disorder

  • 会议论文

  • 发表日期：

    2026年

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  • Xin Zhao,
  • Pan Liu,
  • Yue Wang

摘要

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition with limited treatment options. Terahertz (THz) waves have shown neuromodulatory and behavioral benefits in preclinical models. The hippocampus—a key substrate for cognitive processing—is critically implicated in PTSD pathogenesis, yet how terahertz waves modulate hippocampal gene expression to exert long-term biological effects is unknown. Utilizing a PTSD mouse model, we delivered in vivo 34.5 THz irradiation via a quantum cascade laser coupled to an AgCl:AgBr optical fiber. RNA sequencing of the hippocampus revealed 335 differentially expressed genes (DEGs) (107 up-regulated, 218 down-regulated) post-irradiation. Gene Ontology enrichment analysis implicated these DEGs in critical biological processes, including neurodevelopment, apoptosis regulation, and immune response. Kyoto Encyclopedia of Genes and Genomes pathway analysis further identified significant enrichment in MAPK, TGF-β, GnRH, and ErbB signaling pathways. These findings suggest that THz irradiation may alleviate cognitive deficits in PTSD by modulating neurodevelopmental and immunoregulatory processes through the regulation of key signaling pathways such as MAPK and TGF-β. This study provides initial mechanistic insights into the potential therapeutic application of THz waves for PTSD-related cognitive dysfunction.