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Voltage-gated potassium channels (KV) are essential for action potential repolarization and the modulation of cellular excitability. The KV7.2 channel, a key mediator of the M-current, is implicated in neurological disorders such as neuropathic pain and epilepsy. In this study, we performed molecular dynamics simulations to examine the effects of 51.2 THz stimulation on the KV7.2 channel. Our results indicate that specific THz frequency reduces the potential of mean force (PMF) and changes the secondary structure, thereby promoting more efficient potassium ion conduction. These findings suggest that 51.2 THz may facilitate ion permeation by altering the channel’s energetic and structural properties.

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Molecular Dynamics Simulation of THz-Modulated Potassium Ion Channel

  • 会议论文

  • 发表日期：

    2026年

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  • Yun Shi,
  • Yuankun Sun,
  • Shaomeng Wang,
  • Yubin Gong

摘要

Voltage-gated potassium channels (KV) are essential for action potential repolarization and the modulation of cellular excitability. The KV7.2 channel, a key mediator of the M-current, is implicated in neurological disorders such as neuropathic pain and epilepsy. In this study, we performed molecular dynamics simulations to examine the effects of 51.2 THz stimulation on the KV7.2 channel. Our results indicate that specific THz frequency reduces the potential of mean force (PMF) and changes the secondary structure, thereby promoting more efficient potassium ion conduction. These findings suggest that 51.2 THz may facilitate ion permeation by altering the channel’s energetic and structural properties.