Terahertz (THz) electromagnetic waves, serving as a bridge between electronics and photonics, hold potential applications across various fields, particularly in biophysics and biomedical research. Biological channels, especially ion channels, play a critical role in the functional processes of living organisms by ensuring the selective conduction of specific ions or molecules. In recent years, the biological effects of THz electromagnetic waves have become a focal point of extensive research. This paper reviews recent progress in understanding the interactions between THz wave and biological channels, highlighting key experimental and theoretical findings as well as their potential implications for future biomedical applications.