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The integration of terahertz (THz) sensing with metasurface technology offers a powerful platform for biomolecular detection. Here, we present a quasi-bound state in the continuum (q-BIC) metasurface biosensor designed for the specific and ultrasensitive detection of epithelial cell adhesion molecule (EPCAM). By introducing structural asymmetry in split-ring resonators (SRRs), we experimentally realized a sharp q-BIC mode with a simulated sensitivity of 170 GHz/RIU. Through antibody-functionalized surface chemistry and gold nanoparticle (AuNP)-enhanced THz signal amplification, the biosensor achieves ultrasensitive EPCAM detection across a dynamic range of 1 pM to 100 nM, with a detection limit of 1 pM. This work establishes a new paradigm for THz-based molecular diagnostics and opens avenues for detecting trace biomolecules in clinical and biomedical applications.

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Terahertz Metasurface Sensors Enable Ultrasensitive and Specific Detection of Biomolecules

  • 会议论文

  • 发表日期：

    2026年

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  • Qingzhe Jia,
  • Zhaofu Ma,
  • Yanan Jiao,
  • Zeqiu Lao,
  • Xiaohang Niu,
  • Xiaohui Du

摘要

The integration of terahertz (THz) sensing with metasurface technology offers a powerful platform for biomolecular detection. Here, we present a quasi-bound state in the continuum (q-BIC) metasurface biosensor designed for the specific and ultrasensitive detection of epithelial cell adhesion molecule (EPCAM). By introducing structural asymmetry in split-ring resonators (SRRs), we experimentally realized a sharp q-BIC mode with a simulated sensitivity of 170 GHz/RIU. Through antibody-functionalized surface chemistry and gold nanoparticle (AuNP)-enhanced THz signal amplification, the biosensor achieves ultrasensitive EPCAM detection across a dynamic range of 1 pM to 100 nM, with a detection limit of 1 pM. This work establishes a new paradigm for THz-based molecular diagnostics and opens avenues for detecting trace biomolecules in clinical and biomedical applications.