Mental health and well-being were profoundly impacted by the Coronavirus Disease 2019 (COVID-19) pandemic. Globally, individuals experienced numerous mental health challenges, including heightened stress, anxiety, and psychological distress arising from the fear of illness, uncertainty about the disease, nationwide lockdowns, economic stressors, and disruptions to daily routines. Particularly in India, repeated surges in cases and strain on healthcare systems intensified these challenges, highlighting the need to understand both vulnerabilities and strengths during such adversity. While much mental health research focused on understanding suffering and psychological vulnerability, my study takes a strength-based perspective exploring resilience and how positive expectations for adaptation supported well-being during this unprecedented crisis in the Indian context. The pandemic also caused major changes in research methods, requiring researchers to adapt to numerous unexpected methodological and ethical challenges. Given these unavoidable problems, it is critical to learn from them and devise strategies to continue and successfully conduct timely and relevant studies. Subsequently, this chapter discusses the difficulties experienced while conducting mental health research throughout the COVID-19 phase. Selecting the PhD topic, adapting to a changed working lifestyle, designing research plans, and conducting data collection during challenging periods, such as the pandemic, poor response rates, and ethical dilemmas in soliciting information from respondents during critical times, are among the vital facts discussed. Furthermore, viable recommendations for these are proposed. It is hoped this chapter will serve as a knowledge base for future academics on real-world challenges during crises and help early researchers prepare for and navigate challenging research situations effectively.