The main characteristic of diabetes is chronic hyperglycemia, which is caused by deficiencies in insulin activity. Diabetes is known to worsen with time and lead to a variety of problems, including diabetic neuropathy. The most frequent diabetes consequence, diabetic neuropathy, can be perilous as it can result in paralysis. An increasing amount of research links oxidative stress to diabetic neuropathy. The outcome is oxidative stress when the body produces more oxygen-free radicals than it can remove through antioxidant activity. By directly preventing oxidative damage, antioxidants improve nerve dysfunction in diabetes through a variety of biochemical pathways and locations of action. Significant protection against diabetes is offered by dietetic antioxidants, which are generally produced by nature itself, such as tocopherol, retinol, ascorbic acid, flavonoids, glutathione, polyamines, alpha-lipoic acid, plant polyphenols, and carotenoids. Antioxidant treatment has been shown to retain beta-cell function, protect against oxidative stress-induced apoptosis, as well as lessen problems allied with diabetes.