One frequent consequence of diabetes mellitus is diabetic neuropathy (DN), which affects the peripheral nerve system and causes symptoms including pain, numbness, and decreased motor function. Physical activity and training have showed potential as non-pharmacological treatments for DN. This chapter examines the processes via which consistent exercise aids in maintaining better blood sugar regulation, promoting nerve function, and reducing neuropathic pain in diabetics. Exercise can enhance neurovascular health, lower inflammation, increase muscular strength and mobility, and increase one’s quality of life by combining aerobic, resistance, and flexibility training. Additionally, by reducing risk factors like obesity, high blood pressure, and impaired glucose metabolism, exercise can prevent neuropathy by slowing its progression. Exercise has many potential benefits, but customised exercise programs are required to lower the risk of injury and meet the different needs of people with diabetes. The therapeutic and preventative potential of exercise for diabetic neuropathy is highlighted in this chapter, along with the significance of including it into complete care strategies.