Genome editing can help to manage plant-parasitic nematodes (PPNs) by modifying plant genes to resist infection and potentially editing nematode genes directly. Genome editing, especially Clustered Regularly Interspaced Short Palindromic Repeats / CRISPR-associated protein 9 (CRISPR/Cas9), could help manage PPNs by targeting their virulence genes or enhancing plant resistance. The editing of plant genes, like Arabidopsis thaliana Pleiotropic Aberrant Nematode Binding protein 1 (AtPANB1) in Arabidopsis, reduces nematode infection, with potential for crops like potato. The disrupting genes like subventral-gland regulator-1 in nematodes could reduce infections, with studies showing up to 80% reduction in some cases. Genome editing is a promising biotechnology, though editing nematodes themselves is still in early research stages. There is an ongoing debate about regulatory classification, with some viewing it as a mutation rather than a genetic modification, affecting commercial adoption. This chapter covers the mechanisms, recent findings, challenges, and future directions.