Cold-formed steel (CFS) is becoming a more widespread choice for load-bearing elements in building structures. These built-up conduits frequently have openings for service installation web holes. CFS sections are manufactured by bending or folding flat steel sheet at room temperature. The distinguishing feature of a CFS channel section, stiffened edge web holes is stiffened at their web hole edges to enhance the overall structural section performance. The research investigates the crippling of web behavior of CFS channel sections with stiffened edge web holes subjected to interior-two-flange (ITF) conditions of loading. Web crippling happens when a beam web fails locally due to an excessive load concentrated on a small section of the beam. Here explores the effects of varying hole geometry, examines the impact of stiffened edge holes under ITF loading circumstances using a mix of experimental research and nonlinear finite element analysis (FEA). Channel sections with stiffened hole and plain channel section (without web hole) taken into consideration for comparison. It show that the strength of web crippling of CFS channel sections considerably increased by the stiffened web holes. A parametric analysis perform using the validated FE model to examine the effects of square hole geometry. 4.115% decrease of web crippling strength for circular edge-stiffened web hole compared with channel section without web holes. Parametric studies on geometry of edge-stiffened square holes are investigated. There is increase of web crippling strength for square edge-stiffened web hole for same a/h ratio taken for the circular web hole. Experimental and numerical investigations were conducted on square stiffened edge web holes and compared them with the web crippling strength of plain channel sections. The study reveals that for channels with square edge-stiffened web holes, there is 3.75% increase in strength of web crippling compared to plain channel section.