Global warming and increasing soil temperature boost the growth and turnover of soil microbial communities. Given the high organic nitrogen content of microbial cell walls, this accelerated microbial activity is expected to drive a faster rate of organic nitrogen cycling in the soil. The quantity of nitrogen sequestered or nitrogen pools within terrestrial soils serves to moderate biogeochemical cycling processes. Environmental factors play a crucial role in regulating both the constitution of soil nitrogen pools and the interconversion of nitrogen forms within these pools. Soil microbes play a significant role in maintaining soil health and fertility through various activities such as moderating the N cycle. Thus, the biological reactions of global N cycling are majorly influenced by the soil microbiome and the ecosystem. Changing climatic conditions may therefore impact the dynamics of the soil N cycle. In this chapter, a sincere effort has been made to establish the correlation between the N cycle and soil microbial communities under changing conditions and their effect on soil health.