In the middle and late stages of water flooding development in medium-deep reservoirs, measures based on well pattern and layer series adjustment are characterized by strong coordination between oil and water wells and long effective periods of oil well measures. Traditional evaluation technologies cannot meet the needs of sustainable evaluation for the coordination of oil and water wells. Based on the quantitative characterization of remaining oil, this paper takes oil-water well groups as the evaluation object. It first considers the direct costs of oil and water well measures and incremental operating costs, then uses the natural decline method to predict the production profile after measures, and finally establishes a comprehensive evaluation system for life cycle sustainable development. This system scientifically evaluates the long-term benefits of measures on well groups and small layers, guides the improvement of the scale benefits of oil-water well groups, the formulation and optimization of development plans, benefit early warning, and risk management and control. It provides a reference for the optimal allocation of resources in medium-deep water-flooded reservoirs and decision support for the adjustment of development, production and operation, so as to balance short-term and long-term benefits.