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MicroalgaeMicroalgae are increasingly recognised as sustainable bioresources for producing high-value secondary metabolitesSecondary metabolites with considerable potential in food, nutraceuticalNutraceuticals and pharmaceutical applications, particularly for the prevention and management of metabolic diseasesMetabolic diseases including obesity, diabetes, inflammation and cancer. In this chapter, the biological properties of major microalgal metabolites are summarised, focusing on antioxidant, antimicrobial, anti-diabetic, anti-inflammatory, anti-obesity and anti-cancer activities that are mechanistically linked to oxidative stressOxidative stress reduction, modulation of carbohydrate-digesting enzymes and regulation of key inflammatory and metabolic signalling pathways. Representative taxa such as Spirulina platensisSpirulina platensis, Chlorella vulgaris, Dunaliella salina and Phaeodactylum tricornutum illustrate the breadth of in vitro and in vivo evidence supporting these effects. Nonetheless, clinical validation, standardised bioassays and scalable bioprocesses remain limited. This review underscores the need for integrated metabolic profiling, mechanistic studies and translational research to harness microalgal secondary metabolitesSecondary metabolites as next-generation therapeutic and nutraceuticalNutraceuticals agents against metabolic diseasesMetabolic diseases.

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Microalgal Secondary Metabolites as Emerging Candidates for the Prevention and Management of Metabolic Diseases: A Review

  • 章节

  • 发表日期：

    2026年

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  • Nor Shafiqah Nor Shahril,
  • Mohamad Hafizi Abu Bakar,
  • Mohd Asyraf Kassim,
  • Thiruventhan Karunakaran

摘要

MicroalgaeMicroalgae are increasingly recognised as sustainable bioresources for producing high-value secondary metabolitesSecondary metabolites with considerable potential in food, nutraceuticalNutraceuticals and pharmaceutical applications, particularly for the prevention and management of metabolic diseasesMetabolic diseases including obesity, diabetes, inflammation and cancer. In this chapter, the biological properties of major microalgal metabolites are summarised, focusing on antioxidant, antimicrobial, anti-diabetic, anti-inflammatory, anti-obesity and anti-cancer activities that are mechanistically linked to oxidative stressOxidative stress reduction, modulation of carbohydrate-digesting enzymes and regulation of key inflammatory and metabolic signalling pathways. Representative taxa such as Spirulina platensisSpirulina platensis, Chlorella vulgaris, Dunaliella salina and Phaeodactylum tricornutum illustrate the breadth of in vitro and in vivo evidence supporting these effects. Nonetheless, clinical validation, standardised bioassays and scalable bioprocesses remain limited. This review underscores the need for integrated metabolic profiling, mechanistic studies and translational research to harness microalgal secondary metabolitesSecondary metabolites as next-generation therapeutic and nutraceuticalNutraceuticals agents against metabolic diseasesMetabolic diseases.