Interdisciplinary collaboration is the foundation of providing whole-person, patient-focused care for people with disabilities, addressing their multifaceted physical, cognitive, and psychosocial needs. Evidence-based approaches to implementing interdisciplinary practice in disability care are reviewed, with consideration of theoretical underpinnings, practical applications, and integration into clinical education. Recent studies highlight major guiding frameworks such as the biopsychosocial model, the disability justice framework, and systems theory along with models of care coordination, team-based interventions, and outcome measurement tools. Together, these strategies promote health equity, improve patient satisfaction, enhance care quality, and prepare healthcare students for collaborative practice. Ongoing challenges, including communication breakdown and role ambiguity, are addressed with practical solutions such as standardized protocols and the use of emerging technologies. Current trends, including AI-facilitated care coordination services and expansive global health strategies, emphasize the need for strong evaluation models to ensure effectiveness. Ultimately, interdisciplinary education is highlighted as a catalyst for inclusive and equitable healthcare systems, aligning with global initiatives such as the World Health Organization’s rehabilitation strategies.