Evidence-Based Practice (EBP) has developed as a cornerstone of contemporary disability care, encouraging the systematic use of research evidence, clinical know-how, and client preferences in achieving enhanced outcomes. In this chapter, the principles and practical implementation of EBP in disability services are explored, with a focus on the translation of research into effective clinical decision-making. Evidence-informed interventions are seen to offer benefits such as better rehabilitation outcomes, improved functionality, and increased patient satisfaction. Concurrently, it is also aware of the ongoing barriers to implementation that include the scarcity of disability-specific research, the lack of time in clinical practice, and reluctance to modify well-established practice. To overcome these barriers, the chapter discusses options like professional training, inter-disciplinary collaboration, and the facilitation of a culture that embraces innovation and ongoing learning. A key emphasis is given to the multidisciplinary team (MDT) role, where educators, clinicians, therapists, and caregivers cooperate together to deliver holistic, person-oriented care. Case-based examples, especially in assistive technology and rehabilitation, show how evidence-based practice (EBP)-guided interventions can lead to quantifiable changes in independence, quality of life, and general well-being. In addition, the chapter highlights the need to systematically examine both process and outcome indicators for accountability, efficiency, and sustainability of disability services. Generally, the conclusions highlight that evidence-based, interdisciplinary care represents the gold standard in the care of persons with disabilities and contributes to ethical, coordinated, and outcome-based practice that effectively responds to the complex and changing needs of persons with disabilities.