The Philippines faces rising energy demand, high electricity costs, and increasing environmental impacts, which highlight the urgent need for sustainable practices in higher education institutions (HEIs). This study conducted a comprehensive energy review of Adamson University, a designated establishment under Republic Act No. 11285 due to its annual electricity consumption of 4,338,620 kWh. The Ozanam (OZ) Building being the highest energy-consuming facility, recording nearly 22% of the total, was therefore selected as the focus of the study. The objectives were to identify significant energy use (SEU), establish an energy baseline (EnB), define energy performance indicators (EnPIs), and propose strategies for energy efficiency improvement. Using energy consumption data, statistical analysis, and a Level 1 energy audit, the study confirmed the air-conditioning (AC) system as the dominant SEU, consuming 67% of the building’s annual use. EnPIs were established, including 65 kWh/m2 and 101 kWh/student for the building. The results showed that energy consumption patterns closely followed the academic calendar, with peaks during full semesters and significant drops during breaks. Improvement measures were proposed across technological, operational, and behavioral dimensions. These included replacing non-inverter units with inverters, introducing high-efficiency window-type and split-type ACs, implementing thermal retrofits, enforcing strict runtime controls, and promoting awareness campaigns. Collectively, these interventions could reduce electricity consumption, with the AC system providing the largest savings potential. The study concludes that a systematic, ISO 50001-aligned Energy Management System (EnMS) is essential for HEIs. Beyond cost reduction, such initiative ensures compliance with national energy laws and position universities as sustainability leaders.