This chapter first explains the Japanese approach to adopting Western technology: Wakon-Yosai (a combination of Japanese traditions and Western skills). This approach involves adopting Western technology while not westernising the traditional and philosophical foundations of Japanese culture. Next, I introduce case studies based on Wakon-Yosai and examine its limitations. For instance, innovative start-up products such as Takadiastase and Ajinomoto have been established, grounded on traditional Japanese knowledge related to koji mold umami. Moreover, it is believed that Japan’s first Nobel laureate, Hideki Yukawa, formulated a theory pertaining to quantum mechanics, drawing upon the Cheng–Zhu School and Western science. Conversely, it is noted that the Japanese views of nature has not contributed to the advancement of seismology. Furthermore, this chapter highlights Japanese views of nature in contrast to Western science and also examines the sense of responsibility in Japan, which differs from the West. It is crucial to pay attention to the differences in the sense of responsibility brought about by different views of nature when considering responsibility for environmental issues. Finally, three perspectives—integrating Western science with Japanese views of nature, promoting environmental responsibility and harmony between humans and nature, and avoiding unnecessary intervention while maintaining responsible research and innovation—are proposed to achieve a genuine integration of Japanese views of nature with Western science, technology, and innovation beyond Wakon-Yosai, by utilising Kakishibu as a case study.