Agaricus bisporus, widely known as the white button mushroom, is among the most commonly cultivated edible mushrooms worldwide. It holds both economic and nutritional importance, yet production often faces serious threats from fungal and bacterial diseases such as green mold, dry bubble, cobweb disease, wet bubble, and brown blotch. These infections lower yield and diminish market quality, resulting in notable financial losses. Traditional control still depends heavily on chemical fungicides. However, restrictions on their use, environmental concerns, and the rise of resistant strains have reduced their long-term reliability. In response, growers and researchers are turning toward more sustainable approaches. Promising options include biological control agents, nanotechnology-based delivery methods, and genetic improvement to increase resistance. This review highlights the major pathogens affecting A. bisporus, examines their economic impact, and summarizes recent developments in integrated disease management.