Oilseed-derived microgreens are emerging as high-value functional foods because of their high concentrations of primary metabolites (proteins, essential fatty acids, carbohydrates, minerals) and secondary metabolites (phenolics, glucosinolates, lignans, carotenoids) with numerous antioxidant, anti-inflammatory, cardio-protective, and anti-cancer activities. Compared to mature plants, they exhibit up to 30–40-fold higher micronutrient levels, including vitamins C, E, and K and essential minerals such as iron, zinc, and magnesium. A diverse group of oilseed crops, including sunflower, safflower, mustard, sesame, rapeseed, linseed, niger, groundnut, castor, and soybean, provide distinct nutritional and phytochemical profiles. Oilseed derived microgreen have short growth cycle (7–21 days), low input requirements, and adaptability to controlled environments make them suitable for sustainable production. Multi-OMICS integration (genomics, transcriptomics, proteomics, metabolomics, epigenomics and nutriomics) provides innovative methods to improve flavour, increase post-harvest shelf life, and improve nutrient biosynthesis. In addition to that, association of artificial intelligence with OMICS technology would be a pivotal dynamic to improve the quality and quantity of microgreens and would be a promising resource for climate-resilient smart agriculture. Moreover, oilseed-derived microgreens offer a possible avenue for addressing micronutrient shortages (malnutrition) and improving global health through next-generation functional foods by combining nutritional richness to fulfil the needs of Sustainable Development Goals 2 and 3. In the future, microgreens farming (chemical-free organic green produce) will be a promising small-scale entrepreneurship for marginal farmers and active women as an alternative source of income that will fulfil the daily nutrition needs.