A digital model-based analysis and verification method for the impact resistance performance of key components of separation and detachment connectors is proposed to address the common failure issues in aerospace applications. Taking a certain type of separation and detachment connector as the research object, after in-depth understanding of the connector’s function and structure, and analyzing the failure mechanism of its detachable locking mechanism, the key failure modes are determined. The method involves using digital models to simulate the connector’s unlocking process by establishing high-precision 3D models and performing finite element simulation analysis. The stress levels experienced by key components during unlocking were analyzed. Furthermore, verification experiments were designed to validate the stress simulation results.