When examining the glycan structure of glycoproteins expressed in organisms, we may find glycan structures characteristic of each organism or structures identical to the glycans of glycoproteins expressed in humans. The human-type glycan library has two aspects: the information on the glycan structure of glycoproteins expressed in humans [1] (the human-type glycan library as information) and the glycans with the same structure as the glycans of glycoproteins expressed in humans, prepared from biological materials [2] (easily obtainable materials such as bird and fish eggs, animal organs, tissues) or by organic synthesis, enzymatic synthesis, etc. (the human-type glycan library as a substance). The “human-type glycan library as information” has collected a certain amount of information at the glycoprotein level but not yet at the level of tissues, organs, and cells.

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Human-Type Glycan Library

  • Shin-ichi Nakakita

摘要

When examining the glycan structure of glycoproteins expressed in organisms, we may find glycan structures characteristic of each organism or structures identical to the glycans of glycoproteins expressed in humans. The human-type glycan library has two aspects: the information on the glycan structure of glycoproteins expressed in humans [1] (the human-type glycan library as information) and the glycans with the same structure as the glycans of glycoproteins expressed in humans, prepared from biological materials [2] (easily obtainable materials such as bird and fish eggs, animal organs, tissues) or by organic synthesis, enzymatic synthesis, etc. (the human-type glycan library as a substance). The “human-type glycan library as information” has collected a certain amount of information at the glycoprotein level but not yet at the level of tissues, organs, and cells.