The challenges of twenty-first-century medicine can be said to be care and preventive medicine. The soaring cost of healthcare is a major social issue, and it is uncertain whether the act of medical care itself can make humanity happy. To prevent the onset of diseases, health monitoring such as blood pressure and hyperlipidemia is necessary. For this, it is considered necessary to develop biomarkers that can objectively judge one’s health and aging. It has long been known that glycans change with development, differentiation, cancerization, and aging. For example, the glycans of IgG, which are abundant in the blood, have a deep relationship with aging. Galactose-deficient IgG is attracting attention as a biomarker for chronic inflammation such as inflammatory bowel disease [1] and is also influenced by some genetic factors [2]. To apply IgG glycans to simple clinical tests, it is considered necessary to develop a simpler measurement system that can analyze without the current HPLC or mass spectrometry methods, such as lectin antibody ELISA and without IgG purification. The concept has been shown in Fig. 103.1.