Photocarcinoma, encompassing UV-induced skin cancers such as basal cell carcinoma, squamous cell carcinoma, and melanoma, represents a preventable yet escalating global health challenge driven by environmental factors like ozone depletion and lifestyle behaviors. This chapter delves into the multifaceted ethical considerations shaping its management across clinical practice, research, and public health domains. Central to these discussions is the principle of patient autonomy, exemplified through robust informed consent processes that ensure individuals comprehend treatment risks, benefits, alternatives, and the implications of refusal. Challenges in achieving true understanding, particularly among culturally diverse or low-literacy populations, underscore the need for tailored communication and ongoing dialogue to foster trust and shared decision-making. Equity emerges as a cornerstone ethical imperative, addressing disparities in access to preventive resources like sunscreens and early detection tools, which disproportionately affect low-income, rural, and minority communities. The chapter critiques systemic barriers leading to delayed diagnoses and higher mortality rates, advocating for teledermatology, subsidized interventions, and inclusive research participation to rectify these injustices. Risk communication strategies are examined for their ethical duty to deliver transparent, nonalarmist messaging that counters misinformation while respecting cultural perceptions of sun exposure and skin tone. Privacy concerns in the digital age, particularly with artificial intelligence (AI)-assisted diagnostics and genetic data, highlight vulnerabilities in data anonymization and secondary use, necessitating reconsent mechanisms and antibias algorithms. Research ethics are scrutinized, emphasizing Institutional Review Board (IRB) oversight, the avoidance of therapeutic misconceptions, and posttrial responsibilities to prevent the exploitation of vulnerable groups like the elderly or outdoor workers. Environmental and occupational ethics extend this discourse, calling for regulatory mandates on UV protection in high-risk professions and global stewardship against climate-exacerbated exposures. Public health messaging must balance individual rights with collective well-being, as seen in campaigns regulating tanning beds and promoting occupational safeguards. Ultimately, integrating these ethical principles—autonomy, justice, beneficence, and nonmaleficence—ensures compassionate, equitable responses to photocarcinoma. By embedding ethical foresight into policy and practice, stakeholders can mitigate harm, enhance outcomes, and uphold human dignity in confronting this modifiable disease.