Plant viruses represent one of the significant menaces to the global food supply, as they diminish agricultural output and compromise the standard of food products. Conventional detection and control of plant viruses frequently lack the speed necessary to address sudden outbreaks, are susceptible to misinterpreting visual symptoms, and often fall short in managing disease-spreading vectors. The ongoing emergence of new variants resulting from genetic evolution also hinders successful detection and management. Metal and engineered nanomaterials silver, zinc, iron, gold, silicon, titanium, etc., are reported to hinder virus transmission and vector spread and boost innate plant defense, suggesting their multifarious response to combat viruses. Nanophytovirology is the cutting-edge, multidisciplinary approach wherein nanoparticles are used for diagnostics and therapeutics in the division of plant viral diseases. Nanobiosensors, namely DNA-based, quantum dot-based, antibody-based, optical, and magnetic, are employed for the identification of plant viruses. In the field of disease management, nanoparticles (NPs) can be used as a carrier of antiviral chemicals, therapeutic agents, plant defense inducers, and biostimulants, and for the development of transgenic crops. NPs move through nonprotoplasmic (apoplastic) and protoplasmic (symplastic) pathways of plants, and their effect varies with the nanoparticle’s type, size, charge, and concentration, leading to elevated reactive oxygen species production. The greater prolonged impacts of nanoparticles on flora and fauna, optimal treatment kinetics, potential for retreatment, and the optimization of dose/concentration are factors that should be taken into account for their acceptance. Emerging concepts such as nanofabrication, nano-enabled dsRNA delivery, nanocomposites, RNAi-aided nanoparticle delivery, and nanobased diagnostic kits can offer enhanced possibilities in this context.