Plant viral diseases, particularly those caused by tobamoviruses, continue to challenge global agriculture despite more than a century of scientific advancements. This chapter outlined the interplay between traditional and advanced strategies for managing plant viral diseases, with particular emphasis on tobamoviruses. Conventional methods such as chemical control, resistant varieties, and vector management often fall short due to viral diversity, rapid mutation rates, and environmental concerns. Nanotechnology introduces a novel paradigm by enabling precise delivery systems, early diagnostics, and enhanced plant protection strategies. Nanoparticles (NPs), including silver, gold, silica, and polymer-based types, have demonstrated strong antiviral properties either by directly inactivating viruses or by boosting plant defense mechanisms. One of the most promising applications is the use of nanoparticles for the targeted delivery of antiviral agents or double-stranded RNA (dsRNA), to induce RNA interference (RNAi) in plants. For instance, chitosan and liposome-based nanocarriers have been used to deliver dsRNA effectively in fruit crops like papaya and citrus to combat papaya ringspot virus (PRSV) and citrus tristeza virus (CTV), respectively. Nanobiosensors enable rapid and sensitive detection of early infection, thereby facilitating timely decisions for management of disease. The integration of nanotechnology with precision agriculture tools further enhances disease monitoring and management. The safety, scalability, and regulatory aspects of nano-based interventions are under active research. Nanotechnology holds immense potential to revolutionize viral disease management in fruit crops by offering targeted, eco-friendly, and highly effective solutions for sustainable agriculture, as discussed in this chapter.