Alzheimer’s disease-associated cognitive disabilities pose an increasing challenge for healthcare systems worldwide due to their progressive nature and the significant burden they place on patients and their families. Effective management requires more than symptom control; it demands a comprehensive approach that integrates medical, psychological, and social strategies. Early and accurate diagnosis remains critical, with clinical evaluations, cognitive tests, neuroimaging, and biomarker studies providing the basis for timely and targeted intervention. Pharmacological treatments, such as cholinesterase inhibitors, can provide modest improvements in cognition and daily functioning, while emerging therapies directed at amyloid and tau pathology offer hope for modifying the underlying disease process. Equally important are non-pharmacological strategies. Cognitive rehabilitation programs, regular physical exercise, and thoughtful environmental adjustments help preserve independence and slow functional decline. Caregivers play an indispensable role in this process, as their well-being and preparedness directly influence patient outcomes. Counseling, structured support services, and practical training can ease the emotional and physical demands of long-term care. Taken together, these multidimensional strategies not only address clinical needs but also promote a better quality of life for individuals living with Alzheimer’s disease-associated cognitive disabilities and those who care for them.