Nausea is a subjective symptom characterized by an unpleasant sensation that typically arises in the upper abdomen, anterior chest, or pharynx, creating a desire to vomit. Vomiting is the forceful expulsion of stomach or small intestine contents through the mouth via the esophagus. Diseases causing nausea and vomiting are diverse and not limited to the gastrointestinal system. Chronic nausea and vomitingVomiting pose considerable therapeutic hurdles, including difficulties in determining the etiology and effectively managing symptoms. Consequently, following a comprehensive differential diagnosis, it is essential to ascertain if the illness aligns with chronic nauseaNausea vomiting syndrome (CNVS), cyclic vomitingVomiting syndrome (CVS), or cannabinoid hyperemesis syndrome (CHS)Cannabinoid hyperemesis syndrome (CHS). Specifically, CHS was designated as a functional gastrointestinal condition in 2016 and represents a relatively novel disease concept, underscoring the necessity for awareness.