As noted in other chapters, extremophiles are organisms adapted to thrive in extreme conditions, such as high temperature, pH, and salinity, which are unsuitable for many other life forms. These extremophiles represent a sustainable, cost-effective, and efficient resource for producing valuable materials. They generate extremolytes, extremozymes, biosurfactants, and so on, which are stable and adaptable across various environments. Their products find applications in a wide range of industries, including sustainable agriculture, food, cosmetics, pharmaceuticals, bioremediation, biofuel production, and biorefineries. A significant advantage of extremophiles and their enzymes is their robustness and stability under extreme conditions, facilitating more efficient and consistent bioprocesses. The reaction conditions associated with extremophiles often reduce the risk of contamination and enhance reaction rates, potentially leading to increased productivity and lower operational costs. Some applications of extremophiles have been discussed in previous chapters. This chapter comprehensively enumerates additional applications of extremophiles and their products across various industries not covered in other chapters, while also exploring their future prospects.