This chapter explores the ethical and legal guidance necessary for supervising Interprofessional Education and Collaborative Practice (IPECP), focusing on low- and middle-income countries (LMICs). It emphasizes the importance of ethical frameworks in addressing disparities in healthcare and promoting equitable treatment. Key ethical principles such as informed consent, confidentiality, and respect for diversity are discussed in the context of IPECP supervision. The chapter highlights the unique challenges of practitioners in LMICs, including inadequate infrastructure and socio-cultural factors that influence collaboration. It also examines various ethical decision-making frameworks, such as the Listowel Wingham Hospitals Alliance (LWHA) and the IDEA framework, and their application in healthcare settings. Additionally, the chapter addresses the role of supervisors in upholding ethical standards and provides case studies to illustrate practical applications. The integration of cultural competence and the impact of social determinants of health on IPECP are also explored. The chapter concludes with a discussion on the legal implications of IPECP, including informed consent, data sharing, and the transboundary sharing of biological materials.