Interprofessional education and collaborative practice (IPECP) is increasingly acknowledged as a fundamental paradigm in healthcare education, promoting teamwork and patient-centered care across various disciplines. This chapter introduces a cohesive framework for the design of IPECP curricula by integrating constructivist, behaviorist, cognitive, experiential, and transformative learning theories. This chapter examines how each theoretical perspective informs effective pedagogical strategies, such as simulation-based education, reflective practice, competency-based evaluations, and mentorship approaches. Constructivist and cognitive frameworks steer simulation and problem-based learning, whereas behaviorist concepts guide structured outcomes and assessment processes. Experiential and transformative theories augment learners’ capacities for reflection, adaptation, and development through practical engagement and critical dialogue. The chapter further delineates curriculum development processes, evaluation techniques, and faculty mentoring strategies that are vital for the sustainable execution of IPECP. It addresses obstacles related to cultural adaptation, resource constraints, and faculty readiness, while also highlighting innovative methodologies, such as escape room simulations and virtual IPE frameworks. By aligning theoretical foundations with practical application, this framework offers a strategic guide for educators aspiring to foster effective interprofessional collaboration within varied healthcare environments.