Reinforced concrete multi-story buildings are subjected to lateral forces that cause overturning moments. Irregular or asymmetrical structures are subjected to significant axial and lateral forces, which generate moments that can lead to building failure. This failure can be prevented by using shear walls that provide sufficient stiffness and strength. Shear walls can be designed with or without boundary elements. Based on this problem, this study aims to determine the effect of the location and variation of shear wall thickness with boundary elements in symmetrical and asymmetrical reinforced concrete multi-story buildings. The analysis was conducted on a 7-story building using Response Spectrum Analysis. The structure was analyzed using SeismoStruct software. The structural models were divided into eight types based on the location and thickness variation of the shear walls. The shear walls were located at the outermost corners and the center of each outer side of the building. The displacement of columns and element forces, both columns and beams, from the four models were compared. The analysis results showed that the location significantly affected displacement and element forces, while variations in shear wall thickness did not significantly affect these parameters. The model with shear walls located at the outermost corners of the structure and with variations in shear wall thickness was the model with the best stiffness compared to the other models.