Anchor channels provide an efficient and economical solution for the connection between steel and concrete components. The recent trend towards resource-saving and filigree constructions requires that these connections have to be realized increasingly in concrete structures with a small edge distance. In addition, the application is not only limited to static or quasi-static loads, but they are also used for anchorages, where high-cyclic actions are of interest to prevent fatigue failure. Experimental investigations were performed on cast-in anchor channels located close to the edge to study their fatigue behavior under shear load towards the edge associated with concrete edge failure. The test program included static tests and fatigue tests in the pulsating range under shear load perpendicular to the channel axis and shear loads in the direction of the longitudinal axis of the channel. Serrated anchor channels in combination with serrated channel bolts including a gap filler set were chosen to ensure adequate load transfer within the channel profile. The findings of the experiments are presented in this paper. Based on the test results, a reduction factor for the fatigue resistance against concrete edge failure in both load directions is determined and compared with the current state knowledge.