Electrodynamic therapy (EDT) is an innovative approach in cancer treatment that leverages the unique properties of nanomaterials to induce the generation of reactive oxygen species (ROS) within the tumor microenvironment (TME). This method, which operates under the influence of an external electric field, has shown promise in overcoming the limitations associated with traditional cancer therapies. The use of platinum nanoparticles (Pt NPs) as catalysts is particularly noteworthy, as they facilitate the production of cytotoxic hydroxyl radicals when subjected to an alternating current (AC) electric field. This mechanism, distinct from that of electrochemotherapy (EChT), enables a more homogeneous and less invasive treatment effect across the tumor mass. The integration of EDT with other therapeutic modalities, such as chemotherapy and immunotherapy, further enhances its potential for synergistic antitumor effects. Despite the advancements, challenges remain in optimizing nanomaterial design and understanding the complex interactions within the tumor microenvironment.