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Employing the Izhikevich model, this study demonstrates that increasing DC stimulation intensity enhances firing rates and reduces half-peak widths in both excitatory and inhibitory neurons, while action potential peaks amplify beyond thresholds; notably, membrane potential amplitude shows initial-rise-then-fall dynamics in excitatory neurons versus sustained elevation in inhibitory neurons—revealing intensity-dependent modulation of firing patterns and providing theoretical insights for transcranial DC stimulation applications.​

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Effect of Direct Current Stimulation on Neuronal Firing Patterns Based on IZH Model

  • 会议论文

  • 发表日期：

    2026年

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  • Haijun Zhu,
  • Yujie Zhao,
  • Haoyu Qiu,
  • Yiming Li,
  • Huilan Yang

摘要

Employing the Izhikevich model, this study demonstrates that increasing DC stimulation intensity enhances firing rates and reduces half-peak widths in both excitatory and inhibitory neurons, while action potential peaks amplify beyond thresholds; notably, membrane potential amplitude shows initial-rise-then-fall dynamics in excitatory neurons versus sustained elevation in inhibitory neurons—revealing intensity-dependent modulation of firing patterns and providing theoretical insights for transcranial DC stimulation applications.​