India, while ranking as the world’s fifth-largest economy by nominal GDP, faces significant disparities in economic performance across its urban centers. The nation stands at 125th in terms of per capita income by Purchasing Power Parity (PPP), reflecting considerable intra-national economic inequality. This research examines the hypothesis that a city’s morphological structure influences its economic performance. By employing space syntax analysis and GDP metrics, the study investigates the relationship between urban form and economic outcomes. Many researchers and geographers have proposed theories that explain the relation between regional inequalities and its topological characteristics. The areas with low accessibility usually suffer from economic disparities. To test these phenomena morphological assessment of top metropolitan cities (Delhi, Mumbai, Kolkata, Bangalore, Chennai, Hyderabad, Ahmedabad, Pune, Jaipur, Lucknow, and Bhopal) of India is analyzed with economic indicator. The analysis reveals a discernible correlation between a city’s morphological characteristics and its economic vitality. Cities with well-integrated spatial configurations and efficient connectivity tend to exhibit higher economic performance. The research underscores the importance of urban planning and design in shaping economic success.