Sand control is a critical aspect of oil and gas production operations, aimed at preventing sand influx into the wells and mitigating associated risks. Conventional sand screens serve as primary defense against sand production, however their performance under varying conditions remains a topic of interest. This study evaluated the performance of Metal Mesh Screen (MMS) for sand control in oil production through coupled CFD-DEM simulations and experimental validations. By employing real-scale screen geometry, the simulations provide detailed insights into fluid-particle interactions and screen behavior, enabling the optimization of screen design and operational parameters. The findings have remarkable enhancement which demonstrate a sand retention efficiency of 54.07% and a sand production rate of 62.21%, aligning closely with experimental results. These results underscore the potential of optimizing MMS designs to enhance sand control strategies and improve production efficiency in the oil and gas industry.