The study of co-dependence in relation with the personality traits is important due to its negative impact on mental and health, and well-being. The objective of the present study was to examine the relationships between co-dependence and personality traits at different levels of co-dependence severity. The Multi-factor Co-dependency Scale (Ershova & Sokolova) and the Big Five Questionnaire Barbaranelli and Caprara (2000) were utilised. 279 respondents between 19 and 39 years (68 males, M = 21.7 years; 211 females, M = 24.3 years) completed the online forms under anonymous conditions. The findings indicated a non-linear correlation between variables of co-dependence and personality traits: the strongest association at moderate levels of codependence. The cognitive and regulatory factors of co-dependence are most closely associated with personality traits. Correlation between the BFQ-2 subscale ‘Impulse Control’ and ‘Emotional Control’ with codependence confirmed the hypotheses concerning the emotional sphere of co-dependents: their propensity to suppress, and disregard emotions.