Fasciolosis and fasciolopsiasis are neglected, food-borne zoonotic trematode infections caused by Fasciola spp. (liver flukes) and Fasciolopsis buski (giant intestinal fluke), respectively, and are transmitted through the ingestion of metacercariae-contaminated aquatic vegetation. These parasitic diseases are predominantly endemic in low-income, agrarian regions, particularly in Asia, where close human-animal-environment interactions facilitate transmission. Both infections contribute to significant human morbidity and impose substantial economic losses on livestock production systems. The shared ecological niches, dependence on freshwater snail intermediate hosts, and plant-borne transmission pathways highlight the necessity for integrated surveillance, improved food safety practices, and coordinated One Health-based control and prevention strategies. Fasciolopsiasis is a neglected foodborne, snail-transmitted parasitic zoonotic disease caused by Fasciolopsis buski, the largest intestinal trematode of human. The infection occurs after consumption of raw or improperly cooked aquatic plants like water chestnut, water bamboo, lotus, water caltrop, etc. While often overlooked in global health agendas, it remains endemic in Southeast Asia and the Indian subcontinent, particularly in areas where poverty, poor sanitation, and the consumption of raw aquatic plants intersect.