Norovirus ranks as the second leading cause of childhood diarrhea globally, following rotavirus. Both noroviruses and sapoviruses, members of the Caliciviridae family, are significant pathogens responsible for gastroenteritis. Human noroviruses (HNoV) are particularly notorious for triggering gastroenteritis outbreaks worldwide and are a major contributor to severe diarrhea in children. In contrast, Sapovirus typically induces milder symptoms and is less commonly linked to large-scale outbreaks. Noroviruses are highly contagious and frequently cause self-limiting gastroenteritis, especially in communal settings like hospitals, schools, and nursing homes. Sapovirus infections, on the other hand, primarily affect young children and are generally less severe.