Glanders is a zoonotic disease caused by the bacterium Burkholderia mallei, which predominantly affects horses but can also be transmitted to humans. This chapter presents an overview of glanders, encompassing its transmission, clinical presentation, diagnosis, and control. Humans typically become infected through direct exposure to infected animals or contaminated environments. Glanders in humans can present in diverse clinical manifestations, encompassing localized skin infections, respiratory complications, and systemic sepsis. Diagnosis can be difficult owing to the non-specific character of symptoms and laboratory verification is crucial. This chapter highlights the importance of prompt diagnosis and treatment with appropriate antibiotics. This chapter also emphasizes the imperative for implementing control measures within equine populations, such as surveillance, testing, and quarantine protocols, to mitigate the transmission of glanders to both animal and human hosts.