Ehrlichiosis is a tick-borne zoonotic infection caused by a group of obligate Gram-negative intracellular coccobacilli belonging to the family Anaplasmataceae, in the order Rickettsiales. The pathogens infect white blood cells and can not only thrive but also multiply with ease. Dogs, deer and, cattle serve as reservoirs of infection. The disease is mild and self-limiting in most patients, being easily misdiagnosed as a flu-like illness, such as headache, fever, chills, myalgia, lethargy, and sometimes a rash. The infection can be severe in certain individuals with immunosuppressive diseases or extreme age groups. Some of the laboratory findings include thrombocytopenia, leukopenia, anaemia, altered liver enzymes, and raised creatinine. Molecular and serological tests are essential for confirming the diagnosis and identifying the incriminating pathogen. Clinically, ehrlichiosis mimics rickettsial infections, with overlapping geographic distribution. Hence, it must be considered when patients with a flu-like illness are treated in endemic regions. Otherwise, it can turn fatal if not recognised early and treated promptly. Doxycycline is an effective antibiotic for treating infections. Treatment should not be withheld while diagnostic confirmation is awaited.