The construction industry’s dynamic nature necessitates adaptive strategies for efficient project management. Agile project management, emphasizing flexibility, collaboration, and iterative improvements, offers transformative potential when paired with advanced digital technologies. This paper proposes a digital twin-enabled supply chain management framework underpinned by Agile principles to enhance visibility and traceability in construction projects. By integrating technologies such as digital twins, Building Information Modeling (BIM), GPS, and smart sensors, the framework facilitates iterative planning, continuous feedback, and real-time decision-making. A case study of a water pump house project demonstrates the framework’s capability to optimize material procurement, logistics, and on-site resource distribution. Agile’s focus on stakeholder collaboration and rapid adaptation ensures seamless integration of supply chain processes, improving project efficiency and responsiveness to change. The proposed framework aligns with Agile methodologies to address challenges like data fragmentation and delayed material scheduling, providing a comprehensive approach to managing modern construction projects.