Solid-substrate fermentation (SSF)Solid-substrate fermentation was followed to produce extracellular enzymes and citric acid from cereal and fruit wastesWastes using two filamentous fungi (Aspergillus niger and Neurospora crassa). The SSFSolid-substrate fermentation was followed by two nutrient compositions of substrates. The first composition consists of two cereal floursCereal flours (barley flour and wheat bran) and two fruit wastes (seedSeeds powder of clustered apple, Annona reticulata, and shell powder of groundnut, Arachis hypogaea) with sucrose and mineral solutions. The second composition consists of two cereal floursCereal flours (semolina and ragi powder, Eleusine coracana) and two fruit wastesWastes (seedSeeds powder of sapota, Manilkara zapota, and shell powder of pista, Pistacia vera) with sucrose and mineral solutions. Both compositions were assessed for production of enzymes (amylase, cellulase, maltase, pectinase, and xylanase) and citric acid by SSFSolid-substrate fermentation up to 7 days. In both compositions, A. niger exhibited significantly high production of cellulase, pectinase, and xylanase, whereas N. crassa demonstrated significantly high production of maltase. Overall, in composition 2, production of all enzymes by both fungi was significantly higher than in composition 1. In the first composition, N. crassa produced a significantly higher quantity of citric acid than A. niger, while it was the opposite in the second composition. In composition 2, A. niger formed the highest amount of citric acid, while N. crassa produced almost equal quantities of citric acid in both compositions. Previous studies have discussed the application of agricultural wastesWastes in the production of enzymes and citric acid by SSFSolid-substrate fermentation.