Partially saturated soils are gaining prominence in geotechnical engineering and engineering geology, particularly in the context of extreme climate phenomena. Their intricate response to changing moisture conditions significantly impacts slope stability, foundation design, and infrastructure resilience against climate's extreme phenomena in geotechnical engineering applications. While current constitutive models have shown effectiveness in capturing monotonic Hydro-Mechanical (HM) processes, their predictive capabilities under cyclic loading and varying moisture conditions remain an area with room for further development. This aspect becomes particularly relevant in the context of infrastructures such as railway tracks, where the subsoil is subjected to repeated loading cycles and seasonal moisture fluctuations. This study aims to contribute to this topic by proposing a new HM constitutive model based on the Constitutive Anamnesis Model (CAM) for saturated soils, extending its application to partially saturated conditions. The original CAM effectively predicts the behaviour of fully saturated fine-grained soils under monotonic and cyclic loading, considering soil preloading history. By incorporating partial saturation effects, the extended model offers improved accuracy in simulating the behavior of low and high-plasticity clays under cyclic hydro-mechanical loading, providing a more comprehensive tool for geotechnical engineering applications.