A ground-breaking strategy for raising agricultural output, boosting plant health, and encouraging environmental sustainability is plant nanotechnology. Researchers have created novel approaches to disease management, insect control, nutrient delivery, and precision farming by utilizing nanomaterials and nanoscale instruments. But the quick advancement and use of plant nanotechnology also prompt questions about its long-term viability, possible toxicity, and effects on the environment. This chapter examines methods for using plant nanotechnology sustainably, with a focus on safe nanomaterial application, ethical manufacturing, and environmentally friendly design. It emphasizes how resource waste and environmental contamination can be reduced by using biodegradable and biocompatible nanoparticles, green synthesis techniques, and nano-enabled smart delivery systems. The chapter also covers public awareness campaigns, risk assessment procedures, and regulatory frameworks that are necessary for the proper application of plant nanotechnology. The chapter also explores new areas of research, including bio-nanocomposites, real-time monitoring nanobiosensors, and the combination of nanotechnology with AI and precision agriculture. This chapter offers a thorough road map for using plant nanotechnology’s potential in a way that guarantees societal acceptance, economic feasibility, and environmental safety by addressing both possibilities and difficulties. For academics, decision-makers, and interested parties seeking to match advancements in plant nanotechnology with sustainability concepts, this chapter is a vital resource.